Norflex Plus Orphenadrine 50 tabs


Norflex Plus: instructions for use. Norflex plus para que sirve? 

Norflex plus is a combination drug that consists of Acetaminophen and Orphenadrine.

Acetaminophen belongs to the group of anilides, has pronounced analgesic and antipyretic properties. That is, it is an antipyretic, analgesic and anti-inflammatory agent.

Orphenadrine belongs to the group of myorelaxants of central action, reduces pathological muscle tone. It has parasympatholytic, antihistamine and local anesthetic effect.

The combination Paracetamol Orphenadrine citrate is used in the treatment of conditions such as:

  • Muscle injury.
  • Sprains and strains.
  • Intervertebral disc prolapse.
  • Neck trauma.
  • Acute torticollis and other painful muscle conditions.


Orphenadrine Paracetamol, available as regular and extended-release tablets for oral administration.

For adults: 1 to 2 tablets every 8 hours. It is important that you visit your doctor before taking this medicine, as only a specialist will be able to prescribe treatment for you according to your condition. 

It is not recommended to take Norflex plus for more than 10 days. If the pain does not stop, it is important to see your doctor.

Contraindications for use

The drug is prescribed only by a doctor, as Norflex plus 450 mg has various contraindications, including:

  • hypersensitivity to the components of the drug;
  • recurrent nasal polyps;
  • renal and hepatic insufficiency;
  • acute angle glaucoma;
  • diseases of the neuromuscular apparatus;
  • achalasia of cardia;
  • chronic bronchial diseases (bronchial asthma);
  • pregnancy in the 3rd trimester;
  • persons under 18 years of age;
  • uncontrolled AH;
  • non-specific ulcerative colitis, acute Crohn's disease;
  • people of advanced age (over 65);
  • cachexic people or people with weight deficiency;
  • arterial hypotension (systolic pressure level below 100 mm Hg);
  • epilepsy;
  • mental disorders. 

This is not a complete list of contraindications for Norflex (Paracetamol Orphenadrine), so read the instructions carefully before use. This information is not an official instruction for the product and is for information purposes only.

Side effects

Norflex (Orphenadrine citrate Paracetamol) may cause side effects if the doctor's recommendations are not followed:

1. Cardiovascular system: tachycardia, occurrence of various edemas, arterial hypertension, pain in the heart.

2. Blood and lymphatic system: thrombocytopenia, purpura, leukopenia, pancytopenia, agranulocytosis, anemia (including hemolytic and aplastic anemia), eosinophilia.

3. Nervous system: rapid fatigue; dizziness and headaches; sensory disorders (including paresthesia); memory disorders; disorientation; convulsions; anxiety; tremor; aseptic meningitis; taste disorders; stroke.

4. Visual organs: blurred vision or diplopia, sensations of dryness and pain in the eye area, temporary accommodation disorders, glaucoma.

5. Hearing organs and labyrinth disorders: vertigo, temporary hearing loss, tinnitus.

6. Respiratory system: rhinitis, asthma (including shortness of breath), pneumonia.

7. Digestive system: dry mouth, pain in the epigastric region, loss of appetite, nausea, vomiting, diarrhea, abdominal cramps, dyspepsia, anorexia, flatulence, bloating, gastritis.

8. Renal and urinary tract: urinary retention, urinary incontinence, sodium and water retention, acute renal failure, hematuria, interstitial nephritis, nephrotic syndrome, proteinuria, papillary necrosis.

9. Skin and subcutaneous tissue: urticaria, alopecia, bullous rash, eczema, erythroderma, purpura, Stevens-Johnson syndrome (erythema multiforme), Lyell syndrome, exfoliative dermatitis, photosensitivity reaction, itching.

10. Immunity: allergic reactions, decreased BP, shock and bronchospasm, angioedema (including facial edema), tongue swelling, internal laryngeal edema, including tracheal stenosis, dyspnea.

11. Liver and biliary tract: temporary increase in transaminase activity, liver failure of varying severity, hepatitis, accompanied and not accompanied by jaundice, fulminant hepatitis, liver necrosis, acute liver failure.

12. Reproductive system and mammary glands: impotence, burning in the genital area in women. 26.

13. Psychiatric disorders: euphoria, nervousness, sleep disorders, confusion, emotional lability, disorientation, depression, insomnia, anxiety, nightmares, irritability, psychotic disorders. 

Side effects can be minimized by using the lowest effective dose for the shortest period. Therefore, it is important to follow your doctor's orders and not exceed the recommended dose of the drug. 

If you drink alcohol, consult your doctor before you start taking Norflex (Orphenadrine citrate Paracetamol)

This medicine and alcohol are incompatible and put more strain on your liver and kidneys, which can lead to serious consequences.



Paracetamol. Abuse of Paracetamol can cause a number of serious problems for the body, but the most dangerous thing is that in the first 24 hours of overdose may be asymptomatic. Later, typical symptoms of poisoning, such as nausea, dizziness, and within 72 hours after overdose, abdominal pain with unclear localization appear. After 4-5 days, the failure of the body manifests itself fully in the form of acute liver failure.

Toxic is considered already 10 g of the substance (or 150-200 mg per 1 kg of human body weight), suggests a high chance of hepatotoxicity (liver damage) up to lethal outcome.


If an excessive dose of Acetaminophen has been ingested within 1 hour, it is worth taking an absorbent agent. Plasma concentrations are measured 4 to 6 hours after ingestion.

N - Acetylcysteine can be used 24 hours after taking Acetaminophen, but the greatest productive effect can be achieved within 8 hours of use. The potency of the antidote decreases significantly after this time. Sometimes there is a need for intravenous administration of N - Acetylcysteine.

If there are no signs of vomiting, Methionine may be administered orally. The doctor may also prescribe symptomatic treatment.


Orphenadrine. In an acute overdose of Orphenadrine, the symptoms are found:

  • hot, dry skin; profuse sweating; redness of the face, dry mucous membranes; increased respiratory rate;
  • dilated pupils; motor disorders; muscle tremors; ataxia; tonic and clonic convulsions;
  • hallucinations, anuria; abnormal heart rhythm; heart failure; fatigue;
  • collapse; unconsciousness and impaired electrolyte and acid-base balance.


In case of overdose, indicated:

  • forced diuresis to obtain a large volume of urine;
  • peritoneal dialysis, hemodialysis;
  • supportive therapy, such as intravenous fluids and measures to regulate circulation, depending on symptomatology.

For choline-blocking effects caused by Orphenadrine, treatment with Physostigmine may be tried.

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