Slender Duet: instructions for use
Combined product Slender Duet, which consists of Orlistat 120 mg and L-carnitine 200 mg. Available in capsule format of 90 pieces per package. The product is designed for overweight or obese adult women and men who want to lose weight safely by blocking and removing fat from their bodies.
Slender Duet is indicated to reduce the risk of weight gain again after initial weight loss. It is indicated for obese patients with a BMI β₯30 kg/m2 or β₯27 kg/m2 and other risk factors (diabetes, arterial hypertension, dyslipidemia).
How long can I take Slender Duet with Orlistat?
You can take Slender Duet with Orlistat Mexico for a long period of time, up to four years. Slender Duet (Orlistat and L-carnitine) should be taken every day for maximum effect, especially if your diet is high in fat.
What is the right way to take Slender Duet before or after meals?
The drug should be taken in one capsule three times a day. Slender Duet is taken regardless of meals. Slender Duet capsules with Orlistat should be taken with water only. Not recommended with milk, tea, coffee, alcohol, carbonated or soft drinks.
How much weight can I lose with Slender Duet?
Clinical trials have shown that men and women who took the drug three times a day lost an average of 4.8 kg in the first month, increasing to 7.2 kg after 3 months. The weight loss process is gradual, with no harm to the body.
What is Orlistat?
Included in many lists of the best and safest substances for weight loss in obesity (in combination with a low-calorie diet). It blocks the absorption of fat in the gastrointestinal tract.
The noticeable effect comes after 2 weeks. The result lasts for a year, provided the diet. Side effects are rare. The drug reduces the risk of developing type 2 diabetes.
The active substance of the drug does not affect the functioning of internal systems and organs, since it does not enter the general bloodstream. This determines the absence of addictive and cumulative effects, which makes it possible to take the drug for a long period of time.
The active ingredient of the drug acts only inside the esophagus and does not get into the systemic bloodstream. 7.5-8 hours after using the drug, the value of its concentration in plasma reaches 6ng / ml, indicating a low degree of absorption of Orlistat Mexico.
Most of the drug is excreted with feces. A small amount of the drug remains in the intestine and is broken down to inactive metabolites, which are eliminated from the body via the kidneys and with the bile. The elimination period varies from 3 to 5 days.
Orlistat acts on the same principle as the fat-free diet. At the same time, the body expends accumulated fat deposits for energy needs.
The results of laboratory tests have shown that taking the drug for 90 days in combination with compliance with a hypocaloric diet allows for 10-15% weight loss.
Orlistat blocks lipase enzymes, forming stable bonds with them, and preventing the active breakdown of triglycerides. As a result, the fatty elements pass through the digestive system, but are not digested in it, and are removed from the body with urine and feces.
What is L-carnitine?
L-carnitine is an amino acid, a natural vitamin-like substance, which in its functionality can be described as related to B vitamins (but it is not a B vitamin).
The most significant merit of L-carnitine is that it increases the production of energy (both physical and mental) in the body. The substance helps transport fatty acids from fat depots into muscle cells, which are converted into energy (it transports long-chain fatty acids into the mitochondria through the inner membrane). Without Carnitine's help, fatty acids cannot penetrate the membranes of cellular mitochondria.
L-carnitine is synthesized in the liver, kidneys, and brain, but only at a rate of 25% of the daily requirement. The active substance is produced in the body from gamma-butyrobetaine by the enzyme gamma-butyrobetaine hydroxylase and then enters other tissues. The main part is accumulated in the heart and skeletal muscles (about 95%).
Useful properties of L-carnitine:
- Accelerating metabolism and maintaining optimal body weight
- Increase resistance to stress
- Increase efficiency
- Improve oxygenation of muscle tissue and reduce lactic acid in them.
- Reducing triglyceride levels in the blood
- Stimulation of tissue regeneration
- Stimulation of the brain
- Antioxidant effect
- Removal of toxins from the body
- Protective effect in apoptosis
Protection of the cells of the nervous system from metabolic disorders due to chemical influences.
The substance is also taken as part of the complex therapy for kidney problems.
To correct body weight, it is recommended to combine taking a dietary supplement with a proper diet and physical activity.
Contraindications
The drug should not be used in the following conditions:
- chronic malabsorption syndrome, cholestasis;
- hypersensitivity to Orlistat, l-carnitine, or other drug components;
- during pregnancy and lactation;
- ages under 18 years of age;
- severe liver or kidney disease;
- concomitant use with indirect anticoagulants (Warfarin) or other oral anticoagulants;
- concomitant use with Cyclosporine.
Consult a physician before use, the drug should not be prescribed by yourself.
Can I take Slender Duet during pregnancy and lactation?
Any medicinal product during pregnancy (at any stage) can be used only in accordance with the indications and only on the prescription of the attending physician. Pregnant women should remember that there are no completely safe and completely harmless medicines.
The most dangerous period for the use of any medication, both of chemical and natural origin, is considered to be the first trimester of pregnancy (first 12 gestational weeks) when the fetus develops all organs and systems, which in future will only develop and the formation of the placenta. It is at this stage that the fetus is considered most vulnerable to any chemical and medicinal substances.
During lactation, the active ingredients of the drug penetrate the mother's milk and can cause harm to the baby.
Can diabetic patients take Slender Duet?
Yes, Slender Duet is indicated as additional glycemic control in patients with type II diabetes, overweight and obese individuals receiving control of a low-calorie diet and oral hypoglycemic agents or insulin.
In overweight and obese patients with type 2 diabetes, moderate weight loss (5-10%) was observed to improve glycemic control, lipid profile, and life expectancy.
How to increase the effectiveness of the pills?
- Eliminate from your diet sweets, fried, salty, fatty, and floury foods, with an emphasis on fruits and vegetables.
- If possible, do sports to speed up metabolic processes.
- Drink more than 1,5 l of water per day (not tea, juices, compotes, namely drinking water).
- Completely give up all alcohol and smoking.
Almost 90% of type II diabetics are overweight or obese, with weight being the most important modifiable risk factor. Type II diabetes is associated with high health risks such as premature cardiovascular disease and death.
Therefore, taking Slender Duet will only reduce the course of the disease and its negative effects.
Side effects
The following side effects may occur if the doctor's recommendations are not followed:
- allergic reactions;
- flatulence;
- oily discharge from the rectum;
- fecal incontinence;
- imperative urges to defecation;
- "greasy" stools;
- frequent defecation.
If any symptoms occur as a result of taking the drug, it is important to tell your doctor, who will replace or reduce the dosage of Slender Duet.
Special Directions
It is desirable to distribute the amount of fat evenly at all meals.
During treatment, concomitant pathological processes of obesity may worsen.
Organic cause of obesity, such as hypothyroidism, should be excluded before prescribing the drug.
During treatment, a balanced low-calorie diet in which fat provides no more than 30% of calories is recommended. The likelihood of gastrointestinal side effects increases with high fat content in food (more than 30% of daily calories). Daily intake of fats, carbohydrates and proteins should be distributed between the three main meals. Because Orlistat Mexico decreases absorption of some fat-soluble vitamins, patients must take multivitamin preparations containing fat-soluble vitamins to ensure their adequate intake. In addition, vitamin D and Ξ²-carotene levels may be lower in obese patients than in people who are not obese. Multivitamins should be taken 2 hours before or 2 hours after taking Orlistat, e.g., before going to bed.
Some patients may have increased levels of oxalate in the urine when taking the drug. There have been reports of cases of oxalate nephrolithiasis and oxalate nephropathy with renal failure. When prescribing Slender Duet, renal function should be monitored in patients at risk of renal failure and the drug should be used with caution if there is a history of hyperoxaluria or oxalate nephrolithiasis.
